{"id":1938,"date":"2018-05-17T10:30:28","date_gmt":"2018-05-17T15:30:28","guid":{"rendered":"https:\/\/restruct-lgmd-2021.pantheonsite.io\/?p=1938"},"modified":"2018-05-17T10:30:28","modified_gmt":"2018-05-17T15:30:28","slug":"lgmd-researcher-kathryn-wagner","status":"publish","type":"post","link":"https:\/\/www.lgmd-info.org\/es\/researcher-interview\/2018\/05\/17\/lgmd-researcher-kathryn-wagner\/","title":{"rendered":"INVESTIGADOR EN LGMD: Kathryn Wagner, MD, PhD"},"content":{"rendered":"

LGMD \"En el punto de mira de la investigaci\u00f3n\"<\/strong><\/span><\/h2>\n

 <\/p>\n

INVESTIGADOR LGMD<\/strong>: Dra. Kathryn Wagner\"\"<\/a><\/p>\n

Afiliaci\u00f3n<\/strong>: Instituto Kennedy Krieger<\/p>\n

Funci\u00f3n o cargo<\/strong>: Profesor y Director del Centro de Trastornos Musculares Gen\u00e9ticos<\/p>\n

\u00a0<\/strong><\/p>\n

\u00bfQu\u00e9 educaci\u00f3n y formaci\u00f3n ha recibido para llegar a su puesto actual?<\/strong><\/p>\n

Tras completar un programa de doctorado, hice una residencia en Neurolog\u00eda, seguida de becas en Neuromuscular y Neurogen\u00e9tica. Tambi\u00e9n hice un postdoctorado en Biolog\u00eda Molecular.<\/p>\n

\u00bfQu\u00e9 le llev\u00f3 a dedicarse a la investigaci\u00f3n y, en particular, al estudio de la distrofia muscular?<\/strong><\/p>\n

Mi padre es un destacado cient\u00edfico y siempre supuse que me dedicar\u00eda a la ciencia. Fue bastante tarde en la universidad cuando decid\u00ed que tambi\u00e9n me gustar\u00eda dedicarme a la medicina. Me interes\u00e9 por la distrofia muscular cuando en la escuela de posgrado clon\u00e9 (por casualidad) un gen, la distrobrevina, que tiene algunas similitudes con la distrofina, el gen que falta en la distrofia muscular de Duchenne (DMD). Aprend\u00ed todo lo que pude sobre distrofia muscular y estaba fascinado por los descubrimientos en ese momento de mol\u00e9culas asociadas a la distrofina implicadas en otras distrofias musculares.<\/p>\n

\u00bfQu\u00e9 temas est\u00e1 estudiando?<\/strong><\/p>\n

Dirijo un laboratorio traslacional centrado en el desarrollo de nuevas terapias para la distrofia muscular. Actualmente estudiamos modelos de DMD, distrofia muscular facioescapulohumeral y LGMD. En la cl\u00ednica, estoy estudiando los efectos de un f\u00e1rmaco antimiostatina producido por Pfizer en LGMD2I.<\/p>\n

\u00bfC\u00f3mo ayudar\u00e1 su trabajo a los pacientes? \u00bfTiene un car\u00e1cter m\u00e1s cient\u00edfico o podr\u00eda convertirse en un tratamiento para LGMD o MD en general?<\/strong><\/p>\n

Nuestras investigaciones de laboratorio sobre el AAV y la terapia celular tienen el potencial de convertirse en tratamientos para la LGMD y las MD en general. Si el ensayo cl\u00ednico del f\u00e1rmaco antimiostatina de Pfizer tiene \u00e9xito, ese es el camino m\u00e1s corto hacia el tratamiento.<\/p>\n

\u00bfQu\u00e9 le gustar\u00eda que los pacientes y otras personas interesadas en la LGMD supieran sobre la investigaci\u00f3n (sus propios proyectos y sobre el campo en general)?<\/strong><\/p>\n

La terapia g\u00e9nica ha progresado enormemente en los \u00faltimos a\u00f1os. Es realista suponer que en un futuro pr\u00f3ximo tendremos ensayos de terapia g\u00e9nica sist\u00e9mica en la LGMD. En mi propio trabajo, estamos desarrollando nuevos AAV para que lleguen mejor al m\u00fasculo y no al h\u00edgado.<\/p>\n

\u00bfQu\u00e9 le inspira a seguir trabajando en este campo? <\/strong><\/p>\n

La poblaci\u00f3n de pacientes es irresistible. Se esfuerzan por llevar una vida plena y gratificante a pesar de sus retos f\u00edsicos.<\/p>\n

\u00bfC\u00f3mo pueden los pacientes animarle y ayudarle en su trabajo?<\/strong><\/p>\n

El est\u00edmulo verbal es maravilloso, al igual que el apoyo financiero a nuestra investigaci\u00f3n.<\/p>\n

 <\/p>\n

* Por favor, dale al LIKE, COMENTA y COMPARTE este post para ayudar a concienciar sobre la LGMD.<\/p>\n

* Si desea m\u00e1s informaci\u00f3n sobre la distrofia muscular de cinturas o leer m\u00e1s \"Entrevistas en primer plano\", visite nuestro sitio web en https:\/\/lgmd-info.org<\/a>\u00a0 <\/u><\/p>","protected":false},"excerpt":{"rendered":"

LGMD “Spotlight on Research”   LGMD RESEARCHER: Kathryn Wagner, MD, […]<\/p>","protected":false},"author":1,"featured_media":1941,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[91,92],"tags":[],"class_list":["post-1938","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-researcher-interview","category-researcher"],"acf":[],"yoast_head":"\nLGMD RESEARCHER: Kathryn Wagner, MD, PhD - LGMD Awareness Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.lgmd-info.org\/es\/researcher-interview\/2018\/05\/17\/lgmd-researcher-kathryn-wagner\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"LGMD RESEARCHER: Kathryn Wagner, MD, PhD - 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