{"id":3216,"date":"2020-02-05T12:33:00","date_gmt":"2020-02-05T18:33:00","guid":{"rendered":"https:\/\/restruct-lgmd-2021.pantheonsite.io\/?p=3216"},"modified":"2021-02-19T18:30:53","modified_gmt":"2021-02-19T18:30:53","slug":"lgmd-researcher-dufour","status":"publish","type":"post","link":"https:\/\/www.lgmd-info.org\/es\/researcher-interview\/2020\/02\/05\/lgmd-researcher-dufour\/","title":{"rendered":"INVESTIGADOR LGMD: Antoine Dufour"},"content":{"rendered":"
\"\"<\/figure>\n

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\"LA LGMD EN EL PUNTO DE MIRA DE LA INVESTIGACI\u00d3N\"<\/h2>\n

 <\/p>\n

Investigador: Antoine Dufour<\/p>\n

 <\/p>\n

Afiliaci\u00f3n: Universidad de Calgary<\/p>\n

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Funci\u00f3n o cargo: Profesor asistente<\/p>\n

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W<\/strong>\u00bfQu\u00e9 educaci\u00f3n y formaci\u00f3n ha recibido para llegar a su puesto actual?<\/strong><\/p>\n

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Licenciatura, SUNY Oswego, NY<\/p>\n

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M\u00e1ster y Doctorado, Universidad Stony Brook, NY<\/p>\n

 <\/p>\n

Beca postdoctoral, Universidad de Columbia Brit\u00e1nica, BC, Canad\u00e1<\/p>\n

 <\/p>\n

\u00bfQu\u00e9 le llev\u00f3 a dedicarse a la investigaci\u00f3n y, en particular, al estudio de la distrofia muscular?<\/strong><\/p>\n

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2 razones:<\/p>\n

 <\/p>\n

1- Estudio las tijeras moleculares denominadas proteasas y que tienen m\u00faltiples funciones en todos los aspectos de la vida, funciones biol\u00f3gicas y en diversas distrofias musculares. La distrofia muscular de cinturas tipo 2A (LGMD2A) est\u00e1 causada por una mutaci\u00f3n de una proteasa denominada Calpa\u00edna-3. Estoy trabajando para comprender mejor sus funciones en la biolog\u00eda muscular.<\/p>\n

 <\/p>\n

2- Mi primo mayor ten\u00eda distrofia muscular de Duchenne y crec\u00ed ayud\u00e1ndole con diversas tareas sencillas que ya no pod\u00eda hacer a medida que su enfermedad empeoraba. Yo era s\u00f3lo un ni\u00f1o\/adolescente (falleci\u00f3 cuando yo ten\u00eda 14 a\u00f1os), pero eso dict\u00f3 espec\u00edficamente mi elecci\u00f3n de carrera. Siempre quise convertirme en cient\u00edfico para caracterizar las funciones musculares defectuosas en los MD y comprender mejor c\u00f3mo funciona esta enfermedad. Tras d\u00e9cadas de investigaci\u00f3n, sigue habiendo muchos misterios sobre las MD y eso me parece fascinante.<\/p>\n

 <\/p>\n

\u00bfQu\u00e9 temas est\u00e1 estudiando?<\/strong><\/p>\n

 <\/p>\n

Estudio las tijeras moleculares denominadas proteasas en diversas enfermedades, como distrofias musculares, artritis, enfermedades gastrointestinales y c\u00e1ncer. Utilizamos m\u00e9todos que permiten detectar y rastrear miles de prote\u00ednas. Esto nos permite ver las enfermedades a nivel sist\u00e9mico y controlar m\u00faltiples cambios simult\u00e1neamente. Aplicamos nuestras t\u00e9cnicas para caracterizar la Calpa\u00edna-3 que causa directamente LGMD2A cuando es defectuosa.<\/p>\n

 <\/p>\n

\u00bfC\u00f3mo ayudar\u00e1 su trabajo a los pacientes? \u00bfTiene un car\u00e1cter m\u00e1s cient\u00edfico o podr\u00eda convertirse en un tratamiento para LGMD o MD en general?<\/strong><\/p>\n

 <\/p>\n

Nuestro trabajo es de naturaleza cient\u00edfica y ayudar\u00e1 a caracterizar todas las prote\u00ednas que est\u00e1n cambiadas, afectadas y causantes de las LGMDs. A pesar de d\u00e9cadas de investigaci\u00f3n, tenemos un conocimiento limitado de las LGMD y nuestro trabajo ofrece enfoques imparciales para rastrear miles de cambios e identificar nuevas dianas farmacol\u00f3gicas que permanecen sin identificar en el contexto de las LGMD.<\/p>\n

 <\/p>\n

\u00bfQu\u00e9 le gustar\u00eda que los pacientes y otras personas interesadas en la LGMD supieran sobre la investigaci\u00f3n (sus propios proyectos y sobre el campo en general)?<\/strong><\/p>\n

 <\/p>\n

Nuestro trabajo es imparcial, es decir, no partimos de ideas preconcebidas sobre la LGMD. Adquirimos grandes cantidades de datos e integramos nuestros resultados para identificar nuevas interacciones dentro de esta \"red de interacciones\". Nuestro trabajo crea la posibilidad de explorar nuevas v\u00edas de investigaci\u00f3n y desarrollo. promueve la innovaci\u00f3n constante<\/a> a lo largo de ciclos iterativos. Desarrollamos herramientas cient\u00edficas para encontrar una \"aguja en el pajar\" y seguiremos hallando formas de rastrear peque\u00f1os cambios dentro de las c\u00e9lulas que tienen un profundo impacto en las funciones musculares de los pacientes con LGMD.<\/p>\n

 <\/p>\n

\u00bfQu\u00e9 le inspira a seguir trabajando en este campo? <\/strong><\/p>\n

 <\/p>\n

La emoci\u00f3n de encontrar nuevas interacciones que nadie conoce todav\u00eda e intentar encajar esta nueva \"pieza del puzzle\" dentro de las redes conocidas que conocemos actualmente.<\/p>\n

 <\/p>\n

\u00bfC\u00f3mo pueden los pacientes animarle y ayudarle en su trabajo?<\/strong><\/p>\n

 <\/p>\n

Siga concienciando y comunicando a diversas comunidades c\u00f3mo afectan estas enfermedades a su vida cotidiana. Las redes sociales pueden ser una valiosa herramienta para llegar r\u00e1pidamente a grandes audiencias. Por ejemplo, el reto del cubo de hielo para concienciar sobre la ELA (esclerosis lateral amiotr\u00f3fica) tuvo bastante \u00e9xito. Recaud\u00f3 importantes sumas de dinero para la investigaci\u00f3n y ofreci\u00f3 la oportunidad de educar sobre esta enfermedad a la poblaci\u00f3n en general.<\/p>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":4371,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[91,92],"tags":[],"class_list":["post-3216","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-researcher-interview","category-researcher"],"acf":[],"yoast_head":"\nLGMD RESEARCHER: Antoine Dufour - LGMD Awareness Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.lgmd-info.org\/es\/researcher-interview\/2020\/02\/05\/lgmd-researcher-dufour\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"LGMD RESEARCHER: Antoine Dufour - 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