{"id":1737,"date":"2018-03-04T18:32:55","date_gmt":"2018-03-05T00:32:55","guid":{"rendered":"https:\/\/restruct-lgmd-2021.pantheonsite.io\/?p=1737"},"modified":"2018-03-04T18:32:55","modified_gmt":"2018-03-05T00:32:55","slug":"1737","status":"publish","type":"post","link":"https:\/\/www.lgmd-info.org\/fr\/researcher-interview\/2018\/03\/04\/1737\/","title":{"rendered":"Chercheuse du LGMD : Louise Rodino-Klapac, Ph.D."},"content":{"rendered":"

LGMD \"Spotlight Interview on Research\" (Interview sur la recherche) <\/strong><\/span><\/h2>\n

Chercheur du LGMD :<\/strong> Louise Rodino-Klapac, Ph.D.\"\"<\/a><\/p>\n

Affiliation :\u00a0 <\/strong>L'h\u00f4pital pour enfants Nationwide et Myonexus Therapeutics, Inc.<\/p>\n

R\u00f4le ou position<\/strong>: Professeur associ\u00e9 (NCH) et directeur scientifique (Myonexus)<\/p>\n

 <\/p>\n

 <\/p>\n

Quels sont les \u00e9tudes et la formation qui vous ont permis d'acc\u00e9der \u00e0 votre poste actuel ?<\/strong><\/p>\n

Je suis titulaire d'un doctorat en g\u00e9n\u00e9tique mol\u00e9culaire portant sur le d\u00e9veloppement neuromusculaire. J'ai ensuite effectu\u00e9 un stage post-doctoral en th\u00e9rapie g\u00e9nique \u00e0 l'h\u00f4pital national pour enfants, avec Jerry Mendell comme mentor.<\/p>\n

Qu'est-ce qui vous a amen\u00e9 \u00e0 suivre une carri\u00e8re dans la recherche et \u00e0 \u00e9tudier la dystrophie musculaire en particulier ?<\/strong><\/p>\n

J'ai su tr\u00e8s t\u00f4t que je voulais devenir chercheur. J'\u00e9tais fascin\u00e9e par la g\u00e9n\u00e9tique et par la fa\u00e7on dont les g\u00e8nes d\u00e9fectueux pouvaient causer des maladies. J'ai \u00e9tudi\u00e9 le d\u00e9veloppement neuromusculaire dans le cadre de mes \u00e9tudes sup\u00e9rieures et je souhaitais mettre \u00e0 profit ces connaissances pour mettre au point des traitements pour les maladies musculaires. Heureusement, la recherche sur la dystrophie musculaire est un domaine privil\u00e9gi\u00e9 au Nationwide Children's, ce qui me donne l'occasion de r\u00e9aliser mes objectifs.<\/p>\n

Quels sont les sujets que vous \u00e9tudiez ?<\/strong><\/p>\n

Je d\u00e9veloppe des traitements de th\u00e9rapie g\u00e9nique pour la dystrophie musculaire des ceintures et la dystrophie musculaire de Duchenne et je traduis ces traitements en essais cliniques. Mon laboratoire \u00e9tudie \u00e9galement les m\u00e9canismes pathologiques des dystrophies musculaires des ceintures.<\/p>\n

Comment vos travaux aideront-ils les patients ? Sont-ils plut\u00f4t de nature scientifique ou pourraient-ils devenir un traitement pour les LGMD ou les m\u00e9decins en g\u00e9n\u00e9ral ?<\/strong><\/p>\n

Nos travaux sont directement applicables aux patients. Nous avons des essais cliniques en cours ou imminents pour plusieurs formes de LGMD (2B, 2D, 2E) et nous pr\u00e9voyons des \u00e9tudes cliniques pour d'autres sous-types. Nous sommes tr\u00e8s optimistes et pensons que le remplacement de g\u00e8nes sera un traitement significatif pour les DM.<\/p>\n

Qu'aimeriez-vous que les patients et les autres personnes int\u00e9ress\u00e9es par la LGMD sachent \u00e0 propos de la recherche (vos propres projets et le domaine en g\u00e9n\u00e9ral) ?<\/strong><\/p>\n

La recherche sur la LGMD traverse une p\u00e9riode passionnante. L'am\u00e9lioration des tests g\u00e9n\u00e9tiques et les succ\u00e8s de la th\u00e9rapie g\u00e9nique dans d'autres maladies neuromusculaires ont acc\u00e9l\u00e9r\u00e9 la recherche et les essais cliniques sur la LGMD. Nous pouvons rapidement appliquer \u00e0 une autre forme de LGMD ce que nous avons appris en \u00e9tudiant une autre forme.<\/p>\n

Qu'est-ce qui vous incite \u00e0 continuer \u00e0 travailler dans ce domaine ? <\/strong><\/p>\n

Les patients sont ma plus grande source d'inspiration. Il est tellement gratifiant de savoir que tous les efforts que nous d\u00e9ployons pour mettre au point des traitements cliniques profiteront, je l'esp\u00e8re, aux patients d'une mani\u00e8re tr\u00e8s significative !<\/p>\n

Comment les patients peuvent-ils vous encourager et vous aider dans votre travail ?<\/strong><\/p>\n

Il est extr\u00eamement utile d'entendre les r\u00e9cits des patients (qu'ils soient porteurs d'espoir ou de difficult\u00e9s). Cela nous aide, en tant que chercheurs, \u00e0 conna\u00eetre les d\u00e9fis propres \u00e0 chaque maladie sp\u00e9cifique afin d'adapter les traitements si possible. En outre, c'est une source constante de motivation pour continuer \u00e0 travailler dur en sachant qu'il y a une \u00e9norme \u00e9quipe de supporters derri\u00e8re vous !<\/p>","protected":false},"excerpt":{"rendered":"

LGMD “Spotlight Interview on Research\u201d LGMD Researcher: Louise Rodino-Klapac, Ph.D […]<\/p>","protected":false},"author":1,"featured_media":1735,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[91,92],"tags":[],"class_list":["post-1737","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-researcher-interview","category-researcher"],"acf":[],"yoast_head":"\nLGMD RESEARCHER: Louise Rodino-Klapac, Ph.D - LGMD Awareness Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.lgmd-info.org\/fr\/researcher-interview\/2018\/03\/04\/1737\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"LGMD RESEARCHER: Louise Rodino-Klapac, Ph.D - 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