{"id":5832,"date":"2022-07-06T03:18:54","date_gmt":"2022-07-06T03:18:54","guid":{"rendered":"https:\/\/www.lgmd-info.org\/?p=5832"},"modified":"2024-02-09T14:23:53","modified_gmt":"2024-02-09T14:23:53","slug":"lgmd-researcher-pia-elustondo","status":"publish","type":"post","link":"https:\/\/www.lgmd-info.org\/fr\/researcher-interview\/2022\/07\/06\/lgmd-researcher-pia-elustondo\/","title":{"rendered":"Chercheur du LGMD : Pia Elustondo"},"content":{"rendered":"

\"Pia<\/p>\n

CHERCHEUR DE LGMD :\u00a0 <\/strong>\u00a0Dr. Pia Elustondo<\/p>\n

Affiliation :\u00a0 <\/strong>AGADA Biosciences<\/p>\n

R\u00f4le ou fonction :\u00a0 <\/strong>Director of Research<\/p>\n

Quels sont les \u00e9tudes et la formation qui vous ont permis d'acc\u00e9der \u00e0 votre poste actuel ?<\/strong><\/p>\n

I have a broad background; I studied biochemistry and mechanisms of human disease during my undergraduate and graduate degrees. During my postdoctoral studies, I focused on mitochondrial function in stroke and neurodegenerative disease models (Niemann Pick) before joining the muscular dystrophy community. I wanted to expand my expertise to other disease conditions such as muscular dystrophies, and, in 2018, I joined AGADA Biosciences, a company that specializes in neuromuscular dystrophies. I started in a scientist position and rapidly grew to the position of Director of Research. In my role, I supervise research scientists working on mouse and zebrafish models of muscular dystrophy.<\/p>\n

Qu'est-ce qui vous a amen\u00e9 \u00e0 suivre une carri\u00e8re dans la recherche et \u00e0 \u00e9tudier la dystrophie musculaire en particulier ?<\/strong><\/p>\n

My curiosity led me to do research, and my interest in mitochondria biology connected me with muscular dystrophy because mitochondria play a significant role in muscle function, and if they don\u2019t work well, it can lead to muscle weakness and fatigue. AGADA Biosciences was established to specifically facilitate drug development for rare muscle diseases, including LGMD. One of the objectives of AGADA is to train and develop a scientific workforce that focuses on muscular dystrophy. Pursuing a career doing muscular dystrophy research and training scientists in the area fulfill my career goals.<\/p>\n

Quels sont les sujets que vous \u00e9tudiez ?<\/strong><\/p>\n

We investigate the reasons that lead to muscle dysfunction in muscular dystrophies. We generate and systematically characterize the disease progression and drug efficacy in animal models, including mice and zebrafish. Our aim is to screen and identify interventions (drugs, gene therapy, biologics, etc.) that potentially improve muscle function in these disorders. In addition, we also study the biochemical outcomes to assess drug efficacy in patients participating in muscular dystrophy clinical trials.<\/p>\n

How will your work help patients? Is it more scientific in nature, or might it become a treatment for LGMD<\/strong>ou MD<\/strong>en g\u00e9n\u00e9ral ?<\/strong><\/p>\n

We aim to find safe and effective interventions in animal models of muscular dystrophies. We want to provide data that provides the confidence to transition a drug safely to human clinical trials. Some of our studies are scientific in nature, but our ultimate goal is to use these results as biomarkers of disease progression and response to therapy.<\/p>\n

Qu'aimeriez-vous que les patients et les autres personnes int\u00e9ress\u00e9es par la LGMD sachent \u00e0 propos de la recherche (vos propres projets et le domaine en g\u00e9n\u00e9ral) ?<\/strong><\/p>\n

We want the patients to know that the scientific community has made significant progress in finding treatments for muscular dystrophies such as DMD. This gives us confidence that it is possible to make similar progress in finding effective treatments for LGMDs. Our own research utilizes the latest technologies, such as CRISPR to generate zebrafish models for LGMDs that will allow rapid and cost-effective drug testing.<\/p>\n

Qu'est-ce qui vous incite \u00e0 continuer \u00e0 travailler dans ce domaine ? <\/strong><\/p>\n

I want the quality of life of the patients and caregivers to improve; this is what inspires me to continue doing research.<\/p>\n

Comment les patients peuvent-ils vous encourager et vous aider dans votre travail ?<\/strong><\/p>\n

Patients support these initiatives by participating in clinical trials, raising awareness, and doing fundraisers. This is very motivating for me, and I would say for the entire research community.<\/p>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":3,"featured_media":5831,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[91,92],"tags":[],"class_list":["post-5832","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-researcher-interview","category-researcher"],"acf":[],"yoast_head":"\nLGMD RESEARCHER: Pia Elustondo - LGMD Awareness Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.lgmd-info.org\/fr\/researcher-interview\/2022\/07\/06\/lgmd-researcher-pia-elustondo\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"LGMD RESEARCHER: Pia Elustondo - 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