{"id":2308,"date":"2018-10-24T10:59:24","date_gmt":"2018-10-24T15:59:24","guid":{"rendered":"https:\/\/restruct-lgmd-2021.pantheonsite.io\/?p=2308"},"modified":"2018-10-24T10:59:24","modified_gmt":"2018-10-24T15:59:24","slug":"lgmd-researcher-linda-lowes","status":"publish","type":"post","link":"https:\/\/www.lgmd-info.org\/it\/researcher-interview\/2018\/10\/24\/lgmd-researcher-linda-lowes\/","title":{"rendered":"RICERCATORE LGMD: Linda Lowes"},"content":{"rendered":"

LGMD \"Intervista a riflettori accesi sulla ricerca<\/p>\n

RICERCATORE LGMD:\u00a0 <\/strong>\u00a0Linda Lowes\u00a0\"\"<\/a><\/p>\n

Affiliazione:\u00a0 <\/strong>Ospedale pediatrico nazionale, Columbus, Ohio USA<\/p>\n

Ruolo o posizione:\u00a0\u00a0<\/strong>Sperimentatore principale dell'Istituto di ricerca del Nationwide Children's Hospital, professore associato del Dipartimento di Pediatria dell'Universit\u00e0 statale dell'Ohio.<\/p>\n

Che tipo di istruzione e formazione ha seguito per arrivare alla sua posizione attuale?<\/strong><\/p>\n

Inizialmente ho conseguito la laurea presso la Ohio State University per diventare fisioterapista. Dopo aver lavorato come medico, ho capito che la ricerca clinica mi appassionava, cos\u00ec sono tornata a studiare alla Hahnemann University per ottenere il dottorato di ricerca. Negli ultimi 10 anni ho lavorato nel campo delle malattie rare neuromuscolari.<\/p>\n

Cosa l'ha spinta a intraprendere una carriera nella ricerca e nello studio della distrofia muscolare in particolare?<\/strong><\/p>\n

Dopo la scuola di specializzazione, ho accettato un incarico di insegnamento presso l'Ohio State University. Anche in questo caso, ho capito subito che la mia passione era la ricerca clinica. Ho lasciato l'insegnamento per unirmi al Centro per la terapia genica dell'Istituto di ricerca del Nationwide Children's e lavorare con leader del settore come Jerry Mendell, Kevin Flanigan e Louise Rodino-Klapac. Lavoro anche nelle nostre cliniche per le malattie neuromuscolari. Vedere la scienza di base e i pazienti unirsi \u00e8 un'opportunit\u00e0 straordinaria.<\/p>\n

Quali argomenti state studiando?<\/strong><\/p>\n

Sono a capo di un gruppo di ricercatori che si occupa della selezione e dello sviluppo di misure di outcome. Insieme a Lindsay Alfano, Natalie Miller e Megan Iammarino stiamo raccogliendo dati sulla storia naturale di individui con qualsiasi forma di LGMD per valutare quali misure siano importanti per il paziente, affidabili e sensibili al cambiamento. I dati della storia naturale serviranno anche come controllo esterno, in modo che i dati del trattamento possano essere confrontati con il tasso tradizionale di declino funzionale.<\/p>\n

In che modo il suo lavoro aiuter\u00e0 i pazienti? \u00c8 di natura pi\u00f9 scientifica o potrebbe diventare un trattamento per la LGMD.<\/strong>o MD<\/strong>in generale?<\/strong><\/p>\n

Il nostro lavoro contribuir\u00e0 ad accelerare il processo di sperimentazione clinica, garantendo che i dati raccolti rappresentino accuratamente qualsiasi cambiamento reale nelle capacit\u00e0. Disporre di una misura di esito appropriata pu\u00f2 consentire una sperimentazione pi\u00f9 breve e\/o pi\u00f9 piccola.<\/p>\n

Cosa vorrebbe che i pazienti e gli altri interessati alla LGMD sapessero sulla ricerca (i suoi progetti e il settore in generale)?<\/strong><\/p>\n

Siamo sempre alla ricerca di persone con LGMD che partecipino ai nostri studi di storia naturale. Ai volontari viene chiesto di svolgere attivit\u00e0 con le braccia e le gambe, di rispondere a questionari e di sottoporsi a test di forza muscolare. La partecipazione ai nostri studi comporta pochissimi rischi, se non nessuno, e i dati generati guidano le sperimentazioni terapeutiche.<\/p>\n

Cosa la ispira a continuare a lavorare in questo campo? <\/strong><\/p>\n

Gli straordinari passi avanti compiuti dalla terapia genica rendono concreta la possibilit\u00e0 di avere un impatto significativo sulla vita delle persone affette da LGMD nel corso della mia vita.<\/p>\n

In che modo i pazienti possono incoraggiarvi e aiutare il vostro lavoro?<\/strong><\/p>\n

Contattatemi all'indirizzo NMDtrialinfo@nationwidechildrens.org<\/a>\u00a0\u00a0 In genere testiamo i volontari a Columbus, Ohio, ma abbiamo anche organizzato raccolte di dati in comunit\u00e0 con un gran numero di persone affette da LGMD o in occasione di conferenze di pazienti.<\/p>","protected":false},"excerpt":{"rendered":"

LGMD \u201cSpotlight Interview on Research\u201d LGMD RESEARCHER:\u00a0 \u00a0Linda Lowes\u00a0 Affiliation:\u00a0 […]<\/p>","protected":false},"author":1,"featured_media":2307,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[91,92],"tags":[],"class_list":["post-2308","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-researcher-interview","category-researcher"],"acf":[],"yoast_head":"\nLGMD RESEARCHER:\u00a0 \u00a0Linda Lowes - LGMD Awareness Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.lgmd-info.org\/it\/researcher-interview\/2018\/10\/24\/lgmd-researcher-linda-lowes\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"LGMD RESEARCHER:\u00a0 \u00a0Linda Lowes - 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