{"id":1938,"date":"2018-05-17T10:30:28","date_gmt":"2018-05-17T15:30:28","guid":{"rendered":"https:\/\/restruct-lgmd-2021.pantheonsite.io\/?p=1938"},"modified":"2018-05-17T10:30:28","modified_gmt":"2018-05-17T15:30:28","slug":"lgmd-researcher-kathryn-wagner","status":"publish","type":"post","link":"https:\/\/www.lgmd-info.org\/pl\/researcher-interview\/2018\/05\/17\/lgmd-researcher-kathryn-wagner\/","title":{"rendered":"BADACZ LGMD: Kathryn Wagner, MD, PhD"},"content":{"rendered":"

LGMD \"Spotlight on Research\"<\/strong><\/span><\/h2>\n

 <\/p>\n

BADACZ LGMD<\/strong>: Kathryn Wagner, MD, PhD\"\"<\/a><\/p>\n

Przynale\u017cno\u015b\u0107<\/strong>: Kennedy Krieger Institute<\/p>\n

Rola lub stanowisko<\/strong>: Profesor i dyrektor Centrum Genetycznych Zaburze\u0144 Mi\u0119\u015bniowych<\/p>\n

\u00a0<\/strong><\/p>\n

Jakie wykszta\u0142cenie i szkolenie zdoby\u0142e\u015b, aby osi\u0105gn\u0105\u0107 obecne stanowisko?<\/strong><\/p>\n

Po uko\u0144czeniu programu MD\/PhD odby\u0142em rezydentur\u0119 z neurologii, a nast\u0119pnie stypendia z neurologii i neurogenetyki. Odby\u0142em r\u00f3wnie\u017c sta\u017c podoktorski w dziedzinie biologii molekularnej.<\/p>\n

Co sprawi\u0142o, \u017ce zdecydowa\u0142e\u015b si\u0119 na karier\u0119 naukow\u0105, a w szczeg\u00f3lno\u015bci na badanie dystrofii mi\u0119\u015bniowej?<\/strong><\/p>\n

M\u00f3j ojciec jest wybitnym naukowcem i zawsze zak\u0142ada\u0142em, \u017ce zajm\u0119 si\u0119 naukami \u015bcis\u0142ymi. Dopiero na studiach zdecydowa\u0142em, \u017ce chcia\u0142bym zaj\u0105\u0107 si\u0119 r\u00f3wnie\u017c medycyn\u0105. Zainteresowa\u0142em si\u0119 dystrofi\u0105 mi\u0119\u015bniow\u0105, kiedy w szkole podyplomowej sklonowa\u0142em (przez przypadek) gen, dystrobrewin\u0119, kt\u00f3ry ma pewne podobie\u0144stwa do dystrofiny, genu, kt\u00f3rego brakuje w dystrofii mi\u0119\u015bniowej Duchenne'a (DMD). Dowiedzia\u0142em si\u0119 wszystkiego, co mog\u0142em o dystrofii mi\u0119\u015bniowej i by\u0142em zafascynowany odkryciami w tym czasie cz\u0105steczek zwi\u0105zanych z dystrofin\u0105, kt\u00f3re maj\u0105 wp\u0142yw na inne dystrofie mi\u0119\u015bniowe.<\/p>\n

Jakie tematy studiujesz?<\/strong><\/p>\n

Prowadz\u0119 laboratorium translacyjne, kt\u00f3re koncentruje si\u0119 na opracowywaniu nowych terapii dystrofii mi\u0119\u015bniowej. Obecnie badamy modele DMD, dystrofii mi\u0119\u015bniowej twarzowo-\u0142opatkowo-ramieniowej i LGMD. W klinice badam dzia\u0142anie leku przeciw miostatynie produkowanego przez firm\u0119 Pfizer w LGMD2I.<\/p>\n

W jaki spos\u00f3b Twoja praca pomo\u017ce pacjentom? Czy ma ona bardziej naukowy charakter, czy te\u017c mo\u017ce sta\u0107 si\u0119 metod\u0105 leczenia LGMD lub og\u00f3lnie lekarzy?<\/strong><\/p>\n

Nasze badania laboratoryjne nad AAV i terapi\u0105 kom\u00f3rkow\u0105 maj\u0105 potencja\u0142, aby sta\u0107 si\u0119 metodami leczenia LGMD i og\u00f3lnie chor\u00f3b uk\u0142adu mi\u0119\u015bniowo-szkieletowego. Je\u015bli badanie kliniczne leku przeciw miostatynie firmy Pfizer zako\u0144czy si\u0119 sukcesem, b\u0119dzie to najkr\u00f3tsza droga do leczenia.<\/p>\n

Co chcia\u0142by\u015b, aby pacjenci i inne osoby zainteresowane LGMD wiedzia\u0142y o badaniach (Twoich w\u0142asnych projektach i og\u00f3lnie o tej dziedzinie)?<\/strong><\/p>\n

Terapia genowa poczyni\u0142a ogromne post\u0119py w ci\u0105gu ostatnich kilku lat. Mo\u017cna realistycznie za\u0142o\u017cy\u0107, \u017ce w niedalekiej przysz\u0142o\u015bci przeprowadzimy pr\u00f3by og\u00f3lnoustrojowej terapii genowej w LGMD. W mojej w\u0142asnej pracy opracowujemy nowe AAV, aby lepiej dociera\u0142y do mi\u0119\u015bni, a nie do w\u0105troby.<\/p>\n

Co inspiruje Ci\u0119 do dalszej pracy w tej dziedzinie? <\/strong><\/p>\n

Populacji pacjent\u00f3w nie mo\u017cna si\u0119 oprze\u0107. Staraj\u0105 si\u0119 prowadzi\u0107 satysfakcjonuj\u0105ce \u017cycie pomimo fizycznych wyzwa\u0144.<\/p>\n

W jaki spos\u00f3b pacjenci mog\u0105 Ci\u0119 zach\u0119ci\u0107 i pom\u00f3c Ci w pracy?<\/strong><\/p>\n

S\u0142owna zach\u0119ta jest wspania\u0142a, podobnie jak wsparcie finansowe dla naszych bada\u0144.<\/p>\n

 <\/p>\n

* * * Prosimy o LIKE, COMMENT i SHARE tego postu, aby pom\u00f3c zwi\u0119kszy\u0107 \u015bwiadomo\u015b\u0107 na temat LGMD!<\/p>\n

* * * Aby dowiedzie\u0107 si\u0119 wi\u0119cej o Dystrofii Mi\u0119\u015bniowej Ko\u0144czyn (LGMD) lub przeczyta\u0107 wi\u0119cej \"Wywiad\u00f3w w centrum uwagi\", odwied\u017a nasz\u0105 stron\u0119 internetow\u0105 pod adresem https:\/\/lgmd-info.org<\/a>\u00a0 <\/u><\/p>","protected":false},"excerpt":{"rendered":"

LGMD “Spotlight on Research”   LGMD RESEARCHER: Kathryn Wagner, MD, […]<\/p>","protected":false},"author":1,"featured_media":1941,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[91,92],"tags":[],"class_list":["post-1938","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-researcher-interview","category-researcher"],"acf":[],"yoast_head":"\nLGMD RESEARCHER: Kathryn Wagner, MD, PhD - LGMD Awareness Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.lgmd-info.org\/pl\/researcher-interview\/2018\/05\/17\/lgmd-researcher-kathryn-wagner\/\" \/>\n<meta property=\"og:locale\" content=\"pl_PL\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"LGMD RESEARCHER: Kathryn Wagner, MD, PhD - 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