{"id":3216,"date":"2020-02-05T12:33:00","date_gmt":"2020-02-05T18:33:00","guid":{"rendered":"https:\/\/restruct-lgmd-2021.pantheonsite.io\/?p=3216"},"modified":"2021-02-19T18:30:53","modified_gmt":"2021-02-19T18:30:53","slug":"lgmd-researcher-dufour","status":"publish","type":"post","link":"https:\/\/www.lgmd-info.org\/pl\/researcher-interview\/2020\/02\/05\/lgmd-researcher-dufour\/","title":{"rendered":"BADACZ LGMD: Antoine Dufour"},"content":{"rendered":"
\"\"<\/figure>\n

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\"LGMD SPOTLIGHT ON RESEARCH\"<\/h2>\n

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Badacz: Antoine Dufour<\/p>\n

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Przynale\u017cno\u015b\u0107: Uniwersytet w Calgary<\/p>\n

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Rola lub stanowisko: Adiunkt<\/p>\n

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W<\/strong>Jakie wykszta\u0142cenie i szkolenie zdoby\u0142e\u015b, aby osi\u0105gn\u0105\u0107 obecne stanowisko?<\/strong><\/p>\n

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Licencjat, SUNY Oswego, NY<\/p>\n

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Magister i doktor, Uniwersytet Stony Brook, Nowy Jork<\/p>\n

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Stypendium podoktoranckie, Uniwersytet Kolumbii Brytyjskiej, BC, Kanada<\/p>\n

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Co sprawi\u0142o, \u017ce zdecydowa\u0142e\u015b si\u0119 na karier\u0119 naukow\u0105, a w szczeg\u00f3lno\u015bci na badanie dystrofii mi\u0119\u015bniowej?<\/strong><\/p>\n

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2 powody:<\/p>\n

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1-Badam no\u017cyce molekularne zwane proteazami, kt\u00f3re pe\u0142ni\u0105 wiele funkcji we wszystkich aspektach \u017cycia, funkcjach biologicznych i w r\u00f3\u017cnych dystrofiach mi\u0119\u015bniowych. Dystrofia mi\u0119\u015bniowa ko\u0144czyn typu 2A (LGMD2A) jest spowodowana mutacj\u0105 jednej proteazy zwanej kalpain\u0105-3. Pracuj\u0119 nad lepszym zrozumieniem jej funkcji w biologii mi\u0119\u015bni.<\/p>\n

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2- M\u00f3j starszy kuzyn cierpia\u0142 na dystrofi\u0119 mi\u0119\u015bniow\u0105 Duchenne'a i dorasta\u0142em, pomagaj\u0105c mu w r\u00f3\u017cnych prostych zadaniach, kt\u00f3rych nie m\u00f3g\u0142 ju\u017c wykonywa\u0107 w miar\u0119 pogarszania si\u0119 jego choroby. By\u0142em tylko dzieckiem \/ nastolatkiem (zmar\u0142, gdy mia\u0142em 14 lat), ale to w\u0142a\u015bnie podyktowa\u0142o m\u00f3j wyb\u00f3r kariery. Zawsze chcia\u0142em zosta\u0107 naukowcem, aby scharakteryzowa\u0107 wadliwe funkcje mi\u0119\u015bni w chorobach uk\u0142adu mi\u0119\u015bniowo-szkieletowego i lepiej zrozumie\u0107, jak dzia\u0142a ta choroba. Po dziesi\u0119cioleciach bada\u0144 nadal istnieje wiele tajemnic dotycz\u0105cych stwardnienia rozsianego i uwa\u017cam to za fascynuj\u0105ce.<\/p>\n

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Jakie tematy studiujesz?<\/strong><\/p>\n

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Badam no\u017cyce molekularne zwane proteazami w r\u00f3\u017cnych chorobach, w tym w dystrofiach mi\u0119\u015bniowych, zapaleniu staw\u00f3w, chorobach przewodu pokarmowego i raku. U\u017cywamy metod, kt\u00f3re mog\u0105 wykrywa\u0107 i \u015bledzi\u0107 tysi\u0105ce bia\u0142ek. Pozwala nam to spojrze\u0107 na stany chorobowe na poziomie systemowym i monitorowa\u0107 wiele zmian jednocze\u015bnie. Stosujemy nasze techniki do scharakteryzowania kalpainy-3, kt\u00f3ra w przypadku defektu bezpo\u015brednio powoduje LGMD2A.<\/p>\n

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W jaki spos\u00f3b Twoja praca pomo\u017ce pacjentom? Czy ma ona bardziej naukowy charakter, czy te\u017c mo\u017ce sta\u0107 si\u0119 metod\u0105 leczenia LGMD lub og\u00f3lnie lekarzy?<\/strong><\/p>\n

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Nasza praca ma charakter naukowy i pomo\u017ce scharakteryzowa\u0107 wszystkie bia\u0142ka, kt\u00f3re s\u0105 zmienione, dotkni\u0119te i powoduj\u0105 LGMD. Pomimo dziesi\u0119cioleci bada\u0144, mamy ograniczone zrozumienie chor\u00f3b uk\u0142adu mi\u0119\u015bniowo-szkieletowego, a nasza praca oferuje bezstronne podej\u015bcie do \u015bledzenia tysi\u0119cy zmian i identyfikowania nowych cel\u00f3w lek\u00f3w, kt\u00f3re pozostaj\u0105 niezidentyfikowane w kontek\u015bcie chor\u00f3b uk\u0142adu mi\u0119\u015bniowo-szkieletowego.<\/p>\n

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Co chcia\u0142by\u015b, aby pacjenci i inne osoby zainteresowane LGMD wiedzia\u0142y o badaniach (Twoich w\u0142asnych projektach i og\u00f3lnie o tej dziedzinie)?<\/strong><\/p>\n

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Nasza praca jest bezstronna, co oznacza, \u017ce nie zaczynamy od z g\u00f3ry przyj\u0119tych za\u0142o\u017ce\u0144 dotycz\u0105cych LGMD. Pozyskujemy du\u017ce ilo\u015bci danych i integrujemy nasze wyniki, aby zidentyfikowa\u0107 nowe interakcje w tej \"sieci interakcji\". Nasza praca stwarza potencja\u0142 dla zupe\u0142nie nowych \u015bcie\u017cek eksploracji i promuje ci\u0105g\u0142e innowacje<\/a> w iteracyjnych cyklach. Rozwijamy narz\u0119dzia naukowe, aby znale\u017a\u0107 \"ig\u0142\u0119 w stogu siana\" i b\u0119dziemy nadal znajdowa\u0107 sposoby na \u015bledzenie ma\u0142ych zmian w kom\u00f3rkach, kt\u00f3re maj\u0105 g\u0142\u0119boki wp\u0142yw na funkcje mi\u0119\u015bni u pacjent\u00f3w z LGMD.<\/p>\n

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Co inspiruje Ci\u0119 do dalszej pracy w tej dziedzinie? <\/strong><\/p>\n

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Ekscytacja zwi\u0105zana z odkrywaniem nowych interakcji, o kt\u00f3rych nikt jeszcze nie wie, i pr\u00f3ba dopasowania tego nowego \"elementu uk\u0142adanki\" do znanych nam obecnie sieci.<\/p>\n

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W jaki spos\u00f3b pacjenci mog\u0105 Ci\u0119 zach\u0119ci\u0107 i pom\u00f3c Ci w pracy?<\/strong><\/p>\n

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Kontynuuj podnoszenie \u015bwiadomo\u015bci i informowanie r\u00f3\u017cnych spo\u0142eczno\u015bci o wp\u0142ywie tych chor\u00f3b na codzienne \u017cycie. Media spo\u0142eczno\u015bciowe mog\u0105 by\u0107 cennym narz\u0119dziem umo\u017cliwiaj\u0105cym szybkie dotarcie do du\u017cej liczby odbiorc\u00f3w. Na przyk\u0142ad, wyzwanie Ice Bucket Challenge maj\u0105ce na celu podniesienie \u015bwiadomo\u015bci na temat ALS (stwardnienie zanikowe boczne) odnios\u0142o spory sukces. Zebrano znaczne sumy pieni\u0119dzy na badania i zaoferowano mo\u017cliwo\u015b\u0107 edukowania o tej chorobie og\u00f3\u0142u spo\u0142ecze\u0144stwa.<\/p>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":4371,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[91,92],"tags":[],"class_list":["post-3216","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-researcher-interview","category-researcher"],"acf":[],"yoast_head":"\nLGMD RESEARCHER: Antoine Dufour - LGMD Awareness Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.lgmd-info.org\/pl\/researcher-interview\/2020\/02\/05\/lgmd-researcher-dufour\/\" \/>\n<meta property=\"og:locale\" content=\"pl_PL\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"LGMD RESEARCHER: Antoine Dufour - 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