{"id":3227,"date":"2020-04-15T10:44:29","date_gmt":"2020-04-15T15:44:29","guid":{"rendered":"https:\/\/restruct-lgmd-2021.pantheonsite.io\/?p=3227"},"modified":"2024-02-09T14:24:39","modified_gmt":"2024-02-09T14:24:39","slug":"lgmd-researcher-katherine-mathews","status":"publish","type":"post","link":"https:\/\/www.lgmd-info.org\/pl\/researcher-interview\/2020\/04\/15\/lgmd-researcher-katherine-mathews\/","title":{"rendered":"BADACZ LGMD: Katherine Mathews"},"content":{"rendered":"

Wywiad LGMD Spotlight na temat bada\u0144<\/h2>\n
\"\"<\/figure>\n

BADACZ LGMD:\u00a0 <\/strong>\u00a0Katherine D. Mathews<\/p>\n

Przynale\u017cno\u015b\u0107:\u00a0 <\/strong>Uniwersytet Iowa, wydzia\u0142y pedaitrii i neurologii<\/p>\n

Rola lub stanowisko:<\/strong> \u00a0\u00a0<\/p>\n

Profesor, wydzia\u0142y pediatrii i neurologii<\/p>\n

Wiceprzewodnicz\u0105cy ds. bada\u0144 klinicznych, Wydzia\u0142 Pediatrii<\/p>\n

Jakie wykszta\u0142cenie i szkolenie zdoby\u0142e\u015b, aby osi\u0105gn\u0105\u0107 obecne stanowisko?<\/strong><\/p>\n

Uko\u0144czy\u0142em szkolenie w zakresie pediatrii, neurologii i neurologii dzieci\u0119cej, a nast\u0119pnie uko\u0144czy\u0142em stypendium w dziedzinie genetyki. Moje podstawowe badania naukowe koncentrowa\u0142y si\u0119 na genetycznych podstawach dystrofii mi\u0119\u015bniowej. W p\u00f3\u017aniejszym okresie mojej kariery nast\u0105pi\u0142o logiczne przej\u015bcie do klinicznego skupienia si\u0119 na dystrofii mi\u0119\u015bniowej.<\/p>\n

Co sprawi\u0142o, \u017ce zdecydowa\u0142e\u015b si\u0119 na karier\u0119 naukow\u0105, a w szczeg\u00f3lno\u015bci na badanie dystrofii mi\u0119\u015bniowej?<\/strong><\/p>\n

Zainteresowanie badaniami wynika\u0142o z ch\u0119ci przyczynienia si\u0119 do poprawy opieki na szerszym poziomie ni\u017c tylko dla pacjent\u00f3w, z kt\u00f3rymi spotykam si\u0119 w klinice. Kiedy zaczyna\u0142em swoj\u0105 karier\u0119, nie znali\u015bmy genetycznych ani molekularnych podstaw wi\u0119kszo\u015bci dystrofii mi\u0119\u015bniowych, wi\u0119c nie mieli\u015bmy logicznej podstawy do opracowania terapii. Pocz\u0105tkowo przypadek i przypadek doprowadzi\u0142y do skupienia si\u0119 na badaniach nad dystrofi\u0105 mi\u0119\u015bniow\u0105, ale im lepiej rozumia\u0142em choroby i poznawa\u0142em pacjent\u00f3w, tym bardziej anga\u017cowa\u0142em si\u0119 w t\u0119 grup\u0119 zaburze\u0144.\u00a0<\/p>\n

Jakie tematy studiujesz?<\/strong><\/p>\n

\u00a0Szczeg\u00f3lnie koncentruj\u0119 si\u0119 na klinicznych aspektach dystroglikanopatii, kt\u00f3re obejmuj\u0105 zar\u00f3wno LGMD, jak i wrodzon\u0105 dystrofi\u0119 mi\u0119\u015bniow\u0105. Jestem r\u00f3wnie\u017c cz\u0119\u015bci\u0105 wsp\u00f3lnych wysi\u0142k\u00f3w wspieranych przez CDC w celu zrozumienia epidemiologii wszystkich dystrofii mi\u0119\u015bniowych. Nasz zesp\u00f3\u0142 jest cz\u0119\u015bci\u0105 konsorcjum LGMD GRASP i jest zaanga\u017cowany w inne wsp\u00f3lne badania historii naturalnej. Wreszcie, jestem zaanga\u017cowany w szereg sponsorowanych przez przemys\u0142 bada\u0144 klinicznych badaj\u0105cych potencjalne metody leczenia chor\u00f3b nerwowo-mi\u0119\u015bniowych.<\/p>\n

W jaki spos\u00f3b Twoja praca pomo\u017ce pacjentom? Czy ma ona bardziej naukowy charakter, czy te\u017c mo\u017ce sta\u0107 si\u0119 metod\u0105 leczenia LGMD?<\/strong>lub MD<\/strong>w og\u00f3le?<\/strong><\/p>\n

Moja praca nad dystroglikanopatiami powinna pom\u00f3c w zapewnieniu podstaw do projektowania przysz\u0142ych bada\u0144 klinicznych i zrozumienia naturalnej historii tych chor\u00f3b, aby lepiej opiekowa\u0107 si\u0119 pacjentami ju\u017c teraz. Podobnie, praca epidemiologiczna jest wa\u017cna dla zrozumienia historii naturalnej r\u00f3\u017cnych typ\u00f3w dystrofii mi\u0119\u015bniowej, a tak\u017ce dla firm rozwa\u017caj\u0105cych zaprojektowanie pr\u00f3b leczenia - musz\u0105 wiedzie\u0107, ilu jest pacjent\u00f3w, aby okre\u015bli\u0107, jak zaprojektowa\u0107 badanie, kt\u00f3re jest wykonalne i realistyczne. Mam nadziej\u0119, \u017ce wysi\u0142ki naszych zespo\u0142\u00f3w przyczyni\u0105 si\u0119 do poprawy opieki nad pacjentami z dystrofi\u0105 mi\u0119\u015bniow\u0105.\u00a0<\/p>\n

Co chcia\u0142by\u015b, aby pacjenci i inne osoby zainteresowane LGMD wiedzia\u0142y o badaniach (Twoich w\u0142asnych projektach i og\u00f3lnie o tej dziedzinie)?<\/strong><\/p>\n

Pacjenci musz\u0105 zrozumie\u0107, \u017ce nawet odpowiadanie na proste pytania dotycz\u0105ce ludzi jest cz\u0119sto powoln\u0105 prac\u0105. Jest to szczeg\u00f3lnie prawdziwe w przypadku rzadkich chor\u00f3b. Ludzie s\u0105 skomplikowani i istnieje wiele czynnik\u00f3w, kt\u00f3re przyczyniaj\u0105 si\u0119 do zmienno\u015bci wynik\u00f3w, zar\u00f3wno czynnik\u00f3w genetycznych, jak i niegenetycznych. Cz\u0119\u015bciowo z powodu tej zmienno\u015bci badania nad leczeniem musz\u0105 by\u0107 bardzo starannie zaprojektowane. Jest prawdopodobne, \u017ce niekt\u00f3re pr\u00f3by leczenia nie wyka\u017c\u0105 korzy\u015bci. Jedyn\u0105 pr\u00f3b\u0105 leczenia, kt\u00f3ra jest prawdziw\u0105 pora\u017ck\u0105, jest taka, kt\u00f3ra nie odpowiada na pytanie o korzy\u015bci i bezpiecze\u0144stwo. Pr\u00f3ba leczenia, kt\u00f3ra wykazuje, \u017ce dana terapia nie poprawia wynik\u00f3w, jest pr\u00f3b\u0105 udan\u0105 - pozwala nam przej\u015b\u0107 do innego podej\u015bcia do leczenia.<\/p>\n

Co inspiruje Ci\u0119 do dalszej pracy w tej dziedzinie?<\/strong><\/p>\n

Czuj\u0119 si\u0119 bardzo szcz\u0119\u015bliwy, mog\u0105c wsp\u00f3\u0142pracowa\u0107 z pacjentami, rodzinami i kolegami, kt\u00f3rych spotykam w tej pracy. S\u0105 oni g\u0142\u00f3wn\u0105 si\u0142\u0105 nap\u0119dow\u0105. Po drugie, coraz szybsze pojawianie si\u0119 znacz\u0105cych metod leczenia jest ekscytuj\u0105ce!<\/p>\n

W jaki spos\u00f3b pacjenci mog\u0105 Ci\u0119 zach\u0119ci\u0107 i pom\u00f3c Ci w pracy?<\/strong><\/p>\n

\u00a0Uczestniczy\u0107 w badaniach w miar\u0119 swoich mo\u017cliwo\u015bci. B\u0105d\u017a dobrze poinformowanym pacjentem lub uczestnikiem bada\u0144. Wspieraj bie\u017c\u0105ce finansowanie w tej dziedzinie (NIH, MDA, fundacje zajmuj\u0105ce si\u0119 konkretn\u0105 chorob\u0105, indywidualni badacze). Rozmawiaj ze swoimi federalnymi senatorami i przedstawicielami o znaczeniu ci\u0105g\u0142ego wsparcia NIH dla bada\u0144 w og\u00f3le, w chorobach nerwowo-mi\u0119\u015bniowych i w Twojej konkretnej chorobie. Opowiedz swoj\u0105 histori\u0119.\u00a0<\/p>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":4376,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[91,92],"tags":[],"class_list":["post-3227","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-researcher-interview","category-researcher"],"acf":[],"yoast_head":"\nLGMD RESEARCHER: Katherine Mathews - LGMD Awareness Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.lgmd-info.org\/pl\/researcher-interview\/2020\/04\/15\/lgmd-researcher-katherine-mathews\/\" \/>\n<meta property=\"og:locale\" content=\"pl_PL\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta 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