{"id":1898,"date":"2018-04-22T20:33:00","date_gmt":"2018-04-23T01:33:00","guid":{"rendered":"https:\/\/restruct-lgmd-2021.pantheonsite.io\/?p=1898"},"modified":"2018-04-22T20:33:00","modified_gmt":"2018-04-23T01:33:00","slug":"lgmd-researcher-rita-perlingeiro","status":"publish","type":"post","link":"https:\/\/www.lgmd-info.org\/pt\/researcher-interview\/2018\/04\/22\/lgmd-researcher-rita-perlingeiro\/","title":{"rendered":"INVESTIGADORA LGMD: Rita Perlingeiro"},"content":{"rendered":"

LGMD \"Entrevista em destaque sobre pesquisa\"<\/strong><\/span><\/h2>\n

INVESTIGADOR DE LGMD<\/strong>: Rita Perlingeiro\"\"<\/a><\/p>\n

Filia\u00e7\u00e3o:<\/strong> Universidade de Minnesota<\/p>\n

Fun\u00e7\u00e3o ou cargo:\u00a0 <\/strong>Professor de Medicina<\/p>\n

Que educa\u00e7\u00e3o e forma\u00e7\u00e3o teve para chegar \u00e0 sua posi\u00e7\u00e3o atual?<\/strong><\/p>\n

Doutoramento em Fisiologia pela Universidade de Campinas (UNICAMP) em S\u00e3o Paulo, Brasil, seguido de estudos de p\u00f3s-doutoramento no Whitehead Institute do MIT, Cambridge-MA.<\/p>\n

O que o levou a seguir uma carreira de investiga\u00e7\u00e3o e a estudar a distrofia muscular em particular?<\/strong><\/p>\n

Desde crian\u00e7a que queria ser cientista. Ao longo da minha carreira, a principal motiva\u00e7\u00e3o tem sido o desejo de causar impacto na vida das pessoas atrav\u00e9s da nossa investiga\u00e7\u00e3o.<\/p>\n

Que temas est\u00e3o a estudar?<\/strong><\/p>\n

O principal t\u00f3pico de investiga\u00e7\u00e3o no nosso laborat\u00f3rio \u00e9 o desenvolvimento de terapias baseadas em c\u00e9lulas estaminais para as distrofias musculares, o que inclui uma melhor compreens\u00e3o da assinatura molecular dos progenitores miog\u00e9nicos derivados de c\u00e9lulas estaminais pluripotentes e das c\u00e9lulas estaminais enxertadas, os sinais que permitem que estas c\u00e9lulas se alojem nos m\u00fasculos doentes ap\u00f3s o transplante sist\u00e9mico e promovam a regenera\u00e7\u00e3o muscular, corre\u00e7\u00e3o gen\u00e9tica de c\u00e9lulas estaminais pluripotentes induzidas (iPS) espec\u00edficas de doentes com LGMD para avaliar o potencial de uma terapia aut\u00f3loga baseada em c\u00e9lulas estaminais, e estudos de otimiza\u00e7\u00e3o para a escalabilidade, fabrico e seguran\u00e7a de progenitores miog\u00e9nicos derivados de c\u00e9lulas estaminais pluripotentes para aplica\u00e7\u00f5es terap\u00eauticas.<\/p>\n

Como \u00e9 que o seu trabalho vai ajudar os doentes? \u00c9 de natureza mais cient\u00edfica ou poder\u00e1 tornar-se um tratamento para as LGMD ou para os m\u00e9dicos em geral?<\/strong><\/p>\n

Quando come\u00e7\u00e1mos estes estudos em 2004, eram puramente de ci\u00eancia b\u00e1sica, mas \u00e0 medida que avan\u00e7\u00e1mos na nossa investiga\u00e7\u00e3o ao longo dos anos, sentimos que estamos agora muito mais perto de traduzir esta abordagem num potencial tratamento para a LGMD e outras doen\u00e7as m\u00e9dicas. Tivemos uma reuni\u00e3o pr\u00e9-IND com a FDA em 2017 para alinhar os nossos objectivos a curto e longo prazo.<\/p>\n

O que gostaria que os doentes e outras pessoas interessadas na LGMD soubessem sobre a investiga\u00e7\u00e3o (os seus pr\u00f3prios projectos e a \u00e1rea em geral)?<\/strong><\/p>\n

Existem muitos obst\u00e1culos e muitas inc\u00f3gnitas no caminho para a introdu\u00e7\u00e3o de um novo tratamento terap\u00eautico para os testes de DM, mas o nosso laborat\u00f3rio e outros est\u00e3o a trabalhar sem medo para atingir este objetivo.<\/p>\n

O que o inspira a continuar a trabalhar neste dom\u00ednio? <\/strong><\/p>\n

A possibilidade de o nosso trabalho poder fazer a diferen\u00e7a na vida dos doentes com DM.<\/p>\n

Como \u00e9 que os doentes o podem encorajar e ajudar no seu trabalho?<\/strong><\/p>\n

A for\u00e7a e a esperan\u00e7a dos doentes de MD d\u00e3o-nos constantemente um grande incentivo. Ao longo dos anos, os doentes t\u00eam ajudado o nosso trabalho atrav\u00e9s da doa\u00e7\u00e3o de tecidos e do apoio financeiro e estamos gratos pelo seu apoio.<\/p>\n

 <\/p>\n

* Por favor, GOSTEI, COMENTEI e PARTILHEI esta publica\u00e7\u00e3o para ajudar a aumentar a sensibiliza\u00e7\u00e3o para a LGMD!<\/p>\n

* Para saber mais sobre a distrofia muscular da cintura escapular (LGMD), visite o nosso s\u00edtio Web em: https:\/\/lgmd-info.org<\/a>\u00a0 <\/u><\/p>","protected":false},"excerpt":{"rendered":"

LGMD “Spotlight Interview on Research\u201d LGMD RESEARCHER: Rita Perlingeiro Affiliation: […]<\/p>","protected":false},"author":1,"featured_media":1897,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[91,92],"tags":[],"class_list":["post-1898","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-researcher-interview","category-researcher"],"acf":[],"yoast_head":"\nLGMD RESEARCHER: Rita Perlingeiro - LGMD Awareness Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.lgmd-info.org\/pt\/researcher-interview\/2018\/04\/22\/lgmd-researcher-rita-perlingeiro\/\" \/>\n<meta property=\"og:locale\" content=\"pt_PT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"LGMD RESEARCHER: Rita Perlingeiro - 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