{"id":3216,"date":"2020-02-05T12:33:00","date_gmt":"2020-02-05T18:33:00","guid":{"rendered":"https:\/\/restruct-lgmd-2021.pantheonsite.io\/?p=3216"},"modified":"2021-02-19T18:30:53","modified_gmt":"2021-02-19T18:30:53","slug":"lgmd-researcher-dufour","status":"publish","type":"post","link":"https:\/\/www.lgmd-info.org\/pt\/researcher-interview\/2020\/02\/05\/lgmd-researcher-dufour\/","title":{"rendered":"INVESTIGADOR LGMD: Antoine Dufour"},"content":{"rendered":"
\"\"<\/figure>\n

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\"LGMD EM DESTAQUE NA INVESTIGA\u00c7\u00c3O\"<\/h2>\n

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Investigador: Antoine Dufour<\/p>\n

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Filia\u00e7\u00e3o: Universidade de Calgary<\/p>\n

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Fun\u00e7\u00e3o ou cargo: Professor assistente<\/p>\n

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W<\/strong>que educa\u00e7\u00e3o e forma\u00e7\u00e3o teve para chegar \u00e0 sua posi\u00e7\u00e3o atual?<\/strong><\/p>\n

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Bacharelato, SUNY Oswego, NY<\/p>\n

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Mestrado e Doutoramento, Universidade de Stony Brook, NY<\/p>\n

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Bolsa de p\u00f3s-doutoramento, Universidade de British Columbia, BC, Canad\u00e1<\/p>\n

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O que o levou a seguir uma carreira de investiga\u00e7\u00e3o e a estudar a distrofia muscular em particular?<\/strong><\/p>\n

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2 raz\u00f5es:<\/p>\n

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1- Estudo as tesouras moleculares denominadas proteases e estas t\u00eam m\u00faltiplas fun\u00e7\u00f5es em todos os aspectos da vida, fun\u00e7\u00f5es biol\u00f3gicas e em diversas distrofias musculares. A Distrofia Muscular de Cinturas M\u00faltiplas tipo 2A (LGMD2A) \u00e9 causada por uma muta\u00e7\u00e3o de uma protease denominada Calpa\u00edna-3. Estou a trabalhar para compreender melhor as suas fun\u00e7\u00f5es na biologia muscular.<\/p>\n

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2- O meu primo mais velho tinha Distrofia Muscular de Duchenne e eu cresci a ajud\u00e1-lo em v\u00e1rias tarefas simples que ele j\u00e1 n\u00e3o podia fazer \u00e0 medida que a doen\u00e7a se agravava. Eu era apenas uma crian\u00e7a\/adolescente (ele faleceu quando eu tinha 14 anos), mas isso ditou especificamente a minha escolha de carreira. Sempre quis tornar-me cientista para caraterizar as fun\u00e7\u00f5es musculares defeituosas nos doentes com DM e compreender melhor o funcionamento desta doen\u00e7a. Depois de d\u00e9cadas de investiga\u00e7\u00e3o, ainda h\u00e1 muitos mist\u00e9rios sobre as DM e eu acho isso fascinante.<\/p>\n

 <\/p>\n

Que temas est\u00e3o a estudar?<\/strong><\/p>\n

 <\/p>\n

Estudo as tesouras moleculares denominadas proteases em v\u00e1rias doen\u00e7as, incluindo distrofias musculares, artrite, doen\u00e7as gastrointestinais e cancro. Utilizamos abordagens que podem detetar e seguir milhares de prote\u00ednas. Isto permite-nos ver as doen\u00e7as a n\u00edvel de sistemas e monitorizar v\u00e1rias altera\u00e7\u00f5es em simult\u00e2neo. Aplicamos as nossas t\u00e9cnicas para caraterizar a Calpa\u00edna-3 que, quando defeituosa, causa diretamente a LGMD2A.<\/p>\n

 <\/p>\n

Como \u00e9 que o seu trabalho vai ajudar os doentes? \u00c9 de natureza mais cient\u00edfica ou poder\u00e1 tornar-se um tratamento para as LGMD ou para os m\u00e9dicos em geral?<\/strong><\/p>\n

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O nosso trabalho \u00e9 de natureza cient\u00edfica e ajudar\u00e1 a caraterizar todas as prote\u00ednas que s\u00e3o alteradas, afectadas e causadoras das LGMDs. Apesar de d\u00e9cadas de investiga\u00e7\u00e3o, temos uma compreens\u00e3o limitada das DMs e o nosso trabalho oferece abordagens imparciais para rastrear milhares de altera\u00e7\u00f5es e identificar novos alvos de medicamentos que permanecem por identificar no contexto das DMs.<\/p>\n

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O que gostaria que os doentes e outras pessoas interessadas na LGMD soubessem sobre a investiga\u00e7\u00e3o (os seus pr\u00f3prios projectos e a \u00e1rea em geral)?<\/strong><\/p>\n

 <\/p>\n

O nosso trabalho \u00e9 imparcial, o que significa que n\u00e3o partimos de no\u00e7\u00f5es pr\u00e9-concebidas sobre a LGMD. Adquirimos grandes quantidades de dados e integramos os nossos resultados para identificar novas intera\u00e7\u00f5es dentro desta \"teia de intera\u00e7\u00f5es\". O nosso trabalho cria o potencial para caminhos inteiramente novos de explora\u00e7\u00e3o e promove a inova\u00e7\u00e3o constante<\/a> ao longo de ciclos iterativos. Desenvolvemos ferramentas cient\u00edficas para encontrar uma \"agulha no palheiro\" e continuaremos a encontrar formas de detetar pequenas altera\u00e7\u00f5es nas c\u00e9lulas que t\u00eam um impacto profundo nas fun\u00e7\u00f5es musculares dos doentes com LGMD.<\/p>\n

 <\/p>\n

O que o inspira a continuar a trabalhar neste dom\u00ednio? <\/strong><\/p>\n

 <\/p>\n

A excita\u00e7\u00e3o de encontrar novas intera\u00e7\u00f5es que ainda ningu\u00e9m conhece e tentar encaixar esta nova \"pe\u00e7a do puzzle\" nas redes conhecidas que conhecemos atualmente.<\/p>\n

 <\/p>\n

Como \u00e9 que os doentes o podem encorajar e ajudar no seu trabalho?<\/strong><\/p>\n

 <\/p>\n

Continue a sensibilizar e a comunicar a v\u00e1rias comunidades a forma como estas doen\u00e7as afectam a sua vida quotidiana. As redes sociais podem ser uma ferramenta valiosa para chegar rapidamente a grandes audi\u00eancias. Por exemplo, o desafio do balde de gelo para aumentar a consciencializa\u00e7\u00e3o para a ELA (esclerose lateral amiotr\u00f3fica) foi bastante bem sucedido. Angariou somas significativas de dinheiro para a investiga\u00e7\u00e3o e ofereceu uma oportunidade para educar a popula\u00e7\u00e3o em geral sobre esta doen\u00e7a.<\/p>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":4371,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[91,92],"tags":[],"class_list":["post-3216","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-researcher-interview","category-researcher"],"acf":[],"yoast_head":"\nLGMD RESEARCHER: Antoine Dufour - LGMD Awareness Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.lgmd-info.org\/pt\/researcher-interview\/2020\/02\/05\/lgmd-researcher-dufour\/\" \/>\n<meta property=\"og:locale\" content=\"pt_PT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"LGMD RESEARCHER: Antoine Dufour - 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