{"id":1898,"date":"2018-04-22T20:33:00","date_gmt":"2018-04-23T01:33:00","guid":{"rendered":"https:\/\/restruct-lgmd-2021.pantheonsite.io\/?p=1898"},"modified":"2018-04-22T20:33:00","modified_gmt":"2018-04-23T01:33:00","slug":"lgmd-researcher-rita-perlingeiro","status":"publish","type":"post","link":"https:\/\/www.lgmd-info.org\/tr\/researcher-interview\/2018\/04\/22\/lgmd-researcher-rita-perlingeiro\/","title":{"rendered":"LGMD ARA\u015eTIRMACISI: Rita Perlingeiro"},"content":{"rendered":"

LGMD \"Ara\u015ft\u0131rma \u00dczerine Spotlight R\u00f6portaj\u0131\"<\/strong><\/span><\/h2>\n

LGMD ARA\u015eTIRMACISI<\/strong>: Rita Perlingeiro\"\"<\/a><\/p>\n

Ba\u011fl\u0131l\u0131k:<\/strong> Minnesota \u00dcniversitesi<\/p>\n

Rol veya Pozisyon:\u00a0 <\/strong>T\u0131p Profes\u00f6r\u00fc<\/p>\n

\u015eu anki pozisyonunuza gelmek i\u00e7in hangi e\u011fitim ve \u00f6\u011fretimi ald\u0131n\u0131z?<\/strong><\/p>\n

Brezilya, Sao Paulo'daki Campinas \u00dcniversitesi'nde (UNICAMP) Fizyoloji alan\u0131nda doktora yapm\u0131\u015f, ard\u0131ndan MIT, Cambridge-MA Whitehead Enstit\u00fcs\u00fc'nde doktora sonras\u0131 \u00e7al\u0131\u015fmalarda bulunmu\u015ftur.<\/p>\n

Sizi ara\u015ft\u0131rma alan\u0131nda kariyer yapmaya ve \u00f6zellikle kas distrofisi \u00fczerine \u00e7al\u0131\u015fmaya y\u00f6nlendiren neydi?<\/strong><\/p>\n

\u00c7ocuklu\u011fumdan beri bilim insan\u0131 olmak istiyordum. Kariyerim boyunca ana motivasyonum, ara\u015ft\u0131rmalar\u0131m\u0131z arac\u0131l\u0131\u011f\u0131yla insanlar\u0131n hayatlar\u0131nda bir etki yaratma arzusu oldu.<\/p>\n

Hangi konular \u00fczerinde \u00e7al\u0131\u015f\u0131yorsunuz?<\/strong><\/p>\n

Laboratuvar\u0131m\u0131zdaki ana ara\u015ft\u0131rma konusu, kas distrofileri i\u00e7in k\u00f6k h\u00fccre temelli tedavilerin geli\u015ftirilmesidir ve bu, pluripotent k\u00f6k h\u00fccre kaynakl\u0131 miyojenik progenit\u00f6rlerin ve a\u015f\u0131lanm\u0131\u015f k\u00f6k h\u00fccrelerin molek\u00fcler imzas\u0131n\u0131n, bu h\u00fccrelerin sistemik transplantasyon \u00fczerine hastal\u0131kl\u0131 kaslara yerle\u015fmesine ve kas rejenerasyonunu te\u015fvik etmesine izin veren sinyallerin daha iyi anla\u015f\u0131lmas\u0131n\u0131 i\u00e7erir, Otolog k\u00f6k h\u00fccre tabanl\u0131 bir tedavinin potansiyelini de\u011ferlendirmek i\u00e7in LGMD hastas\u0131na \u00f6zg\u00fc ind\u00fcklenmi\u015f pluripotent k\u00f6k (iPS) h\u00fccrelerin gen d\u00fczeltmesi ve terap\u00f6tik uygulamalar i\u00e7in pluripotent k\u00f6k h\u00fccre kaynakl\u0131 miyojenik progenit\u00f6rlerin \u00f6l\u00e7eklenebilirli\u011fi, \u00fcretimi ve g\u00fcvenli\u011fi i\u00e7in optimizasyon \u00e7al\u0131\u015fmalar\u0131.<\/p>\n

\u00c7al\u0131\u015fman\u0131z hastalara nas\u0131l yard\u0131mc\u0131 olacak? Do\u011fas\u0131 gere\u011fi daha bilimsel mi yoksa LGMD'ler veya genel olarak MD'ler i\u00e7in bir tedavi olabilir mi?<\/strong><\/p>\n

Bu \u00e7al\u0131\u015fmalara 2004 y\u0131l\u0131nda ba\u015flad\u0131\u011f\u0131m\u0131zda tamamen temel bilim niteli\u011findeydi, ancak y\u0131llar i\u00e7inde ara\u015ft\u0131rmam\u0131z\u0131 ilerlettik\u00e7e, bu yakla\u015f\u0131m\u0131 LGMD ve di\u011fer MD'ler i\u00e7in potansiyel bir tedaviye d\u00f6n\u00fc\u015ft\u00fcrmeye art\u0131k \u00e7ok daha yak\u0131n oldu\u011fumuzu hissediyoruz. K\u0131sa ve uzun vadeli hedeflerimizi hizalamak i\u00e7in 2017 y\u0131l\u0131nda FDA ile bir \u00f6n-IND toplant\u0131s\u0131 yapt\u0131k.<\/p>\n

Hastalar\u0131n ve LGMD ile ilgilenen di\u011fer ki\u015filerin ara\u015ft\u0131rma hakk\u0131nda (kendi projeleriniz ve genel olarak alan hakk\u0131nda) ne bilmelerini istersiniz?<\/strong><\/p>\n

MD testi i\u00e7in yeni bir terap\u00f6tik tedavi getirme yolunda pek \u00e7ok engel ve bilinmeyen var, ancak laboratuvar\u0131m\u0131z ve di\u011ferleri bu hedefe do\u011fru korkusuzca \u00e7al\u0131\u015f\u0131yor.<\/p>\n

Bu alanda \u00e7al\u0131\u015fmaya devam etmek i\u00e7in size ilham veren nedir? <\/strong><\/p>\n

\u00c7al\u0131\u015fmalar\u0131m\u0131z\u0131n MD'li hastalar\u0131n hayatlar\u0131nda bir fark yaratma olas\u0131l\u0131\u011f\u0131.<\/p>\n

Hastalar sizi nas\u0131l te\u015fvik edebilir ve \u00e7al\u0131\u015fmalar\u0131n\u0131za nas\u0131l yard\u0131mc\u0131 olabilir?<\/strong><\/p>\n

MD hastalar\u0131n\u0131n g\u00fcc\u00fc ve umudu bize s\u00fcrekli olarak \u00f6nemli bir cesaret veriyor. Y\u0131llar boyunca hastalar doku ba\u011f\u0131\u015f\u0131 ve mali destek yoluyla \u00e7al\u0131\u015fmalar\u0131m\u0131za yard\u0131mc\u0131 oldular ve destekleri i\u00e7in minnettar\u0131z.<\/p>\n

 <\/p>\n

* * * LGMD konusunda fark\u0131ndal\u0131k yaratmaya yard\u0131mc\u0131 olmak i\u00e7in l\u00fctfen bu g\u00f6nderiyi BE\u011eEN\u0130N, YORUM YAPIN ve PAYLA\u015eIN!<\/p>\n

* * * Limb Girdle Muscular Dystrophy (LGMD) hakk\u0131nda daha fazla bilgi edinmek i\u00e7in l\u00fctfen web sitemizi ziyaret edin: https:\/\/lgmd-info.org<\/a>\u00a0 <\/u><\/p>","protected":false},"excerpt":{"rendered":"

LGMD “Spotlight Interview on Research\u201d LGMD RESEARCHER: Rita Perlingeiro Affiliation: […]<\/p>","protected":false},"author":1,"featured_media":1897,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[91,92],"tags":[],"class_list":["post-1898","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-researcher-interview","category-researcher"],"acf":[],"yoast_head":"\nLGMD RESEARCHER: Rita Perlingeiro - LGMD Awareness Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.lgmd-info.org\/tr\/researcher-interview\/2018\/04\/22\/lgmd-researcher-rita-perlingeiro\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"LGMD RESEARCHER: Rita Perlingeiro - 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