{"id":2308,"date":"2018-10-24T10:59:24","date_gmt":"2018-10-24T15:59:24","guid":{"rendered":"https:\/\/restruct-lgmd-2021.pantheonsite.io\/?p=2308"},"modified":"2018-10-24T10:59:24","modified_gmt":"2018-10-24T15:59:24","slug":"lgmd-researcher-linda-lowes","status":"publish","type":"post","link":"https:\/\/www.lgmd-info.org\/tr\/researcher-interview\/2018\/10\/24\/lgmd-researcher-linda-lowes\/","title":{"rendered":"LGMD ARA\u015eTIRMACISI: Linda Lowes"},"content":{"rendered":"

LGMD \"Ara\u015ft\u0131rma \u00dczerine Spotlight R\u00f6portaj\u0131\"<\/p>\n

LGMD ARA\u015eTIRMACISI:\u00a0 <\/strong>\u00a0Linda Lowes\u00a0\"\"<\/a><\/p>\n

Ba\u011fl\u0131l\u0131k:\u00a0 <\/strong>Nationwide \u00c7ocuk Hastanesi, Columbus, Ohio ABD<\/p>\n

Rol veya Pozisyon:\u00a0\u00a0<\/strong>Ba\u015f Ara\u015ft\u0131rmac\u0131, Nationwide \u00c7ocuk Hastanesi Ara\u015ft\u0131rma Enstit\u00fcs\u00fc, Do\u00e7ent Pediatri B\u00f6l\u00fcm\u00fc, Ohio Eyalet \u00dcniversitesi<\/p>\n

\u015eu anki pozisyonunuza gelmek i\u00e7in hangi e\u011fitim ve \u00f6\u011fretimi ald\u0131n\u0131z?<\/strong><\/p>\n

Lisans derecemi Ohio Eyalet \u00dcniversitesi'nden fizyoterapist olmak i\u00e7in ald\u0131m. Bir klinisyen olarak \u00e7al\u0131\u015ft\u0131ktan sonra klinik ara\u015ft\u0131rmalar konusunda tutkulu oldu\u011fumu fark ettim ve doktoram\u0131 almak i\u00e7in Hahnemann \u00dcniversitesi'nde okula geri d\u00f6nd\u00fcm. Son 10 y\u0131ld\u0131r n\u00f6rom\u00fcsk\u00fcler nadir hastal\u0131klar alan\u0131nda \u00e7al\u0131\u015f\u0131yorum.<\/p>\n

Sizi ara\u015ft\u0131rma alan\u0131nda kariyer yapmaya ve \u00f6zellikle kas distrofisi \u00fczerine \u00e7al\u0131\u015fmaya y\u00f6nlendiren neydi?<\/strong><\/p>\n

Lisans\u00fcst\u00fc okuldan sonra Ohio Eyalet \u00dcniversitesi'nde \u00f6\u011fretim g\u00f6revlisi olarak \u00e7al\u0131\u015fmaya ba\u015flad\u0131m. Yine k\u0131sa s\u00fcrede tutkumun klinik ara\u015ft\u0131rmalarda oldu\u011funu \u00f6\u011frendim. Jerry Mendell, Kevin Flanigan ve Louise Rodino-Klapac gibi alan\u0131n liderleriyle \u00e7al\u0131\u015fmak \u00fczere Nationwide Children's Ara\u015ft\u0131rma Enstit\u00fcs\u00fc'ndeki Gen Terapisi Merkezi'ne kat\u0131lmak i\u00e7in \u00f6\u011fretmenlikten ayr\u0131ld\u0131m. Ayr\u0131ca n\u00f6rom\u00fcsk\u00fcler hastal\u0131k kliniklerimizde de \u00e7al\u0131\u015f\u0131yorum. Temel bilim ve hastalar\u0131n bir araya geldi\u011fini g\u00f6rmek inan\u0131lmaz bir f\u0131rsat.<\/p>\n

Hangi konular \u00fczerinde \u00e7al\u0131\u015f\u0131yorsunuz?<\/strong><\/p>\n

Sonu\u00e7 \u00f6l\u00e7\u00fct\u00fc se\u00e7imi ve geli\u015ftirilmesini inceleyen bir ara\u015ft\u0131rmac\u0131 ekibine liderlik ediyorum. Lindsay Alfano, Natalie Miller ve Megan Iammarino ile birlikte, hangi \u00f6l\u00e7\u00fcmlerin hasta i\u00e7in \u00f6nemli, g\u00fcvenilir ve de\u011fi\u015fime duyarl\u0131 oldu\u011funu de\u011ferlendirmek i\u00e7in herhangi bir LGMD formuna sahip bireyler \u00fczerinde do\u011fal ge\u00e7mi\u015f verileri topluyoruz. Do\u011fal ge\u00e7mi\u015f verileri ayn\u0131 zamanda harici bir kontrol g\u00f6revi g\u00f6recek ve b\u00f6ylece tedavi verileri geleneksel fonksiyonel gerileme oran\u0131yla kar\u015f\u0131la\u015ft\u0131r\u0131labilecektir.<\/p>\n

\u00c7al\u0131\u015fman\u0131z hastalara nas\u0131l yard\u0131mc\u0131 olacak? Do\u011fas\u0131 gere\u011fi daha bilimsel mi yoksa LGMD i\u00e7in bir tedavi olabilir mi?<\/strong>s veya MD<\/strong>genel olarak?<\/strong><\/p>\n

\u00c7al\u0131\u015fmam\u0131z, toplanan verilerin yeteneklerdeki herhangi bir ger\u00e7ek de\u011fi\u015fikli\u011fi do\u011fru bir \u015fekilde temsil etmesini sa\u011flayarak klinik deneme s\u00fcrecini h\u0131zland\u0131rmaya yard\u0131mc\u0131 olacakt\u0131r. Uygun sonu\u00e7 \u00f6l\u00e7\u00fct\u00fcne sahip olmak daha k\u0131sa ve\/veya daha k\u00fc\u00e7\u00fck bir denemeye olanak sa\u011flayabilir.<\/p>\n

Hastalar\u0131n ve LGMD ile ilgilenen di\u011fer ki\u015filerin ara\u015ft\u0131rma hakk\u0131nda (kendi projeleriniz ve genel olarak alan hakk\u0131nda) ne bilmelerini istersiniz?<\/strong><\/p>\n

Do\u011fal tarih \u00e7al\u0131\u015fmalar\u0131m\u0131za kat\u0131lmalar\u0131 i\u00e7in her zaman LGMD'li bireyler ar\u0131yoruz. G\u00f6n\u00fcll\u00fclerden kol ve bacaklar\u0131yla aktiviteleri tamamlamalar\u0131, anketleri yan\u0131tlamalar\u0131 ve kas g\u00fc\u00e7lerini test etmemize izin vermeleri istenmektedir. \u00c7al\u0131\u015fmalar\u0131m\u0131zda yer alman\u0131n \u00e7ok az riski vard\u0131r ve elde edilen veriler tedavi denemelerine rehberlik eder.<\/p>\n

Bu alanda \u00e7al\u0131\u015fmaya devam etmek i\u00e7in size ilham veren nedir? <\/strong><\/p>\n

Gen terapisi \u00e7al\u0131\u015fmalar\u0131ndaki inan\u0131lmaz ilerlemeler, LGMD'li bireylerin ya\u015famlar\u0131n\u0131 benim ya\u015fam s\u00fcrem i\u00e7inde \u00f6nemli \u00f6l\u00e7\u00fcde etkileyebilece\u011fimizi ger\u00e7ek bir olas\u0131l\u0131k haline getirmektedir.<\/p>\n

Hastalar sizi nas\u0131l te\u015fvik edebilir ve \u00e7al\u0131\u015fmalar\u0131n\u0131za nas\u0131l yard\u0131mc\u0131 olabilir?<\/strong><\/p>\n

L\u00fctfen benimle ileti\u015fime ge\u00e7in NMDtrialinfo@nationwidechildrens.org<\/a>\u00a0\u00a0 G\u00f6n\u00fcll\u00fcleri genellikle Columbus, Ohio'da test ediyoruz, ancak LGMD'li \u00e7ok say\u0131da bireyin bulundu\u011fu topluluklarda veya hasta konferanslar\u0131nda da veri koleksiyonlar\u0131 olu\u015fturduk.<\/p>","protected":false},"excerpt":{"rendered":"

LGMD \u201cSpotlight Interview on Research\u201d LGMD RESEARCHER:\u00a0 \u00a0Linda Lowes\u00a0 Affiliation:\u00a0 […]<\/p>","protected":false},"author":1,"featured_media":2307,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[91,92],"tags":[],"class_list":["post-2308","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-researcher-interview","category-researcher"],"acf":[],"yoast_head":"\nLGMD RESEARCHER:\u00a0 \u00a0Linda Lowes - LGMD Awareness Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.lgmd-info.org\/tr\/researcher-interview\/2018\/10\/24\/lgmd-researcher-linda-lowes\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"LGMD RESEARCHER:\u00a0 \u00a0Linda Lowes - 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