{"id":3227,"date":"2020-04-15T10:44:29","date_gmt":"2020-04-15T15:44:29","guid":{"rendered":"https:\/\/restruct-lgmd-2021.pantheonsite.io\/?p=3227"},"modified":"2024-02-09T14:24:39","modified_gmt":"2024-02-09T14:24:39","slug":"lgmd-researcher-katherine-mathews","status":"publish","type":"post","link":"https:\/\/www.lgmd-info.org\/tr\/researcher-interview\/2020\/04\/15\/lgmd-researcher-katherine-mathews\/","title":{"rendered":"LGMD ARA\u015eTIRMACISI: Katherine Mathews"},"content":{"rendered":"

Ara\u015ft\u0131rma \u00dczerine LGMD Spotlight R\u00f6portaj\u0131<\/h2>\n
\"\"<\/figure>\n

LGMD ARA\u015eTIRMACISI:\u00a0 <\/strong>\u00a0Katherine D. Mathews<\/p>\n

Ba\u011fl\u0131l\u0131k:\u00a0 <\/strong>Iowa \u00dcniversitesi, Pedaitri ve N\u00f6roloji B\u00f6l\u00fcmleri<\/p>\n

Rol veya Pozisyon:<\/strong> \u00a0\u00a0<\/p>\n

Profes\u00f6r, Pediatri ve N\u00f6roloji B\u00f6l\u00fcmleri<\/p>\n

Pediatri B\u00f6l\u00fcm\u00fc, Sinir Hastal\u0131klar\u0131 Ara\u015ft\u0131rma Ba\u015fkan Yard\u0131mc\u0131s\u0131<\/p>\n

\u015eu anki pozisyonunuza gelmek i\u00e7in hangi e\u011fitim ve \u00f6\u011fretimi ald\u0131n\u0131z?<\/strong><\/p>\n

Pediatri, n\u00f6roloji ve \u00e7ocuk n\u00f6rolojisi alanlar\u0131nda uzmanl\u0131k e\u011fitimimi tamamlad\u0131ktan sonra genetik alan\u0131nda uzmanl\u0131k e\u011fitimi ald\u0131m. Temel bilim ara\u015ft\u0131rmalar\u0131m kas distrofisinin genetik temeline odakland\u0131. Kariyerimin ilerleyen d\u00f6nemlerinde kas distrofisine klinik olarak odaklanmak mant\u0131kl\u0131 bir ge\u00e7i\u015f oldu.<\/p>\n

Sizi ara\u015ft\u0131rma alan\u0131nda kariyer yapmaya ve \u00f6zellikle kas distrofisi \u00fczerine \u00e7al\u0131\u015fmaya y\u00f6nlendiren neydi?<\/strong><\/p>\n

Ara\u015ft\u0131rmaya olan ilgim, yaln\u0131zca klinikte g\u00f6rd\u00fc\u011f\u00fcm hastalar i\u00e7in de\u011fil, daha geni\u015f bir d\u00fczeyde bak\u0131m\u0131n iyile\u015ftirilmesine katk\u0131da bulunma arzusundan kaynakland\u0131. Kariyerime ba\u015flad\u0131\u011f\u0131mda, \u00e7o\u011fu kas distrofisinin genetik veya molek\u00fcler temelini bilmiyorduk, bu nedenle tedavi geli\u015ftirmek i\u00e7in mant\u0131kl\u0131 bir temelimiz yoktu. Ba\u015flang\u0131\u00e7ta, tesad\u00fcfler ve \u015fans eseri kas distrofisi ara\u015ft\u0131rmalar\u0131na odakland\u0131m, ancak hastal\u0131klar\u0131 daha iyi anlad\u0131k\u00e7a ve hastalar\u0131 tan\u0131d\u0131k\u00e7a, bu hastal\u0131k grubuna daha fazla ba\u011fland\u0131m.\u00a0<\/p>\n

Hangi konular \u00fczerinde \u00e7al\u0131\u015f\u0131yorsunuz?<\/strong><\/p>\n

\u00a0Hem LGMD hem de konjenital musk\u00fcler distrofiyi kapsayan distroglikanopatilerin klinik y\u00f6nlerine \u00f6zellikle odaklan\u0131yorum. Ayr\u0131ca, t\u00fcm kas distrofilerinin epidemiyolojisini anlamak i\u00e7in CDC taraf\u0131ndan desteklenen ortak bir \u00e7aban\u0131n par\u00e7as\u0131y\u0131m. Ekibimiz LGMD GRASP konsorsiyumunun bir par\u00e7as\u0131d\u0131r ve di\u011fer i\u015fbirlik\u00e7i do\u011fal tarih \u00e7al\u0131\u015fmalar\u0131nda yer almaktad\u0131r. Son olarak, n\u00f6rom\u00fcsk\u00fcler hastal\u0131klar i\u00e7in potansiyel tedavileri ara\u015ft\u0131ran end\u00fcstri destekli bir dizi klinik \u00e7al\u0131\u015fmada yer al\u0131yorum.<\/p>\n

\u00c7al\u0131\u015fman\u0131z hastalara nas\u0131l yard\u0131mc\u0131 olacak? Do\u011fas\u0131 gere\u011fi daha bilimsel mi yoksa LGMD i\u00e7in bir tedavi olabilir mi?<\/strong>s veya MD<\/strong>genel olarak?<\/strong><\/p>\n

Distroglikanopatiler \u00fczerine yapt\u0131\u011f\u0131m \u00e7al\u0131\u015fma, gelecekteki klinik ara\u015ft\u0131rmalar\u0131n tasarlanmas\u0131na ve bu hastal\u0131klar\u0131n do\u011fal seyrinin anla\u015f\u0131larak hastalara daha iyi bak\u0131m sa\u011flanmas\u0131na yard\u0131mc\u0131 olacakt\u0131r. Benzer \u015fekilde, epidemiyoloji \u00e7al\u0131\u015fmas\u0131, farkl\u0131 kas distrofisi t\u00fcrlerinin do\u011fal seyrini anlamak ve tedavi denemeleri tasarlamay\u0131 d\u00fc\u015f\u00fcnen \u015firketler i\u00e7in \u00f6nemlidir - uygulanabilir ve ger\u00e7ek\u00e7i bir denemeyi nas\u0131l tasarlayacaklar\u0131n\u0131 belirlemek i\u00e7in ka\u00e7 hasta oldu\u011funu bilmeleri gerekir. Ekiplerimizin \u00e7abalar\u0131n\u0131n kas distrofisi hastalar\u0131n\u0131n daha iyi y\u00f6netilmesine katk\u0131da bulunmas\u0131n\u0131 umuyorum.\u00a0<\/p>\n

Hastalar\u0131n ve LGMD ile ilgilenen di\u011fer ki\u015filerin ara\u015ft\u0131rma hakk\u0131nda (kendi projeleriniz ve genel olarak alan hakk\u0131nda) ne bilmelerini istersiniz?<\/strong><\/p>\n

Hastalar\u0131n, insanlarla ilgili basit sorular\u0131 yan\u0131tlaman\u0131n bile genellikle yava\u015f bir i\u015f oldu\u011funu anlamalar\u0131 gerekir. Bu durum \u00f6zellikle nadir hastal\u0131klar i\u00e7in ge\u00e7erlidir. \u0130nsanlar karma\u015f\u0131kt\u0131r ve hem genetik fakt\u00f6rler hem de genetik olmayan fakt\u00f6rler olmak \u00fczere sonu\u00e7lardaki de\u011fi\u015fkenli\u011fe katk\u0131da bulunan pek \u00e7ok \u015fey vard\u0131r. K\u0131smen bu de\u011fi\u015fkenlik nedeniyle, tedavi \u00e7al\u0131\u015fmalar\u0131n\u0131n \u00e7ok dikkatli bir \u015fekilde tasarlanmas\u0131 gerekir. Baz\u0131 tedavi denemelerinin fayda g\u00f6stermemesi muhtemeldir. ger\u00e7ek bir ba\u015far\u0131s\u0131zl\u0131k olan tek tedavi denemesi, fayda ve g\u00fcvenlik sorusunu yan\u0131tlayamayan bir denemedir. belirli bir tedavinin sonu\u00e7lar\u0131 iyile\u015ftirmedi\u011fini g\u00f6steren bir tedavi denemesi ba\u015far\u0131l\u0131 bir denemedir - farkl\u0131 bir tedavi yakla\u015f\u0131m\u0131na ge\u00e7memizi sa\u011flar.<\/p>\n

Bu alanda \u00e7al\u0131\u015fmaya devam etmek i\u00e7in size ilham veren nedir?<\/strong><\/p>\n

Bu i\u015f sayesinde tan\u0131\u015ft\u0131\u011f\u0131m hastalar, aileler ve meslekta\u015flar\u0131mla etkile\u015fimde bulundu\u011fum i\u00e7in kendimi \u00e7ok \u015fansl\u0131 hissediyorum. Onlar birincil itici g\u00fc\u00e7. \u0130kinci olarak, anlaml\u0131 tedavilerin h\u0131zlanan vaadi heyecan verici!<\/p>\n

Hastalar sizi nas\u0131l te\u015fvik edebilir ve \u00e7al\u0131\u015fmalar\u0131n\u0131za nas\u0131l yard\u0131mc\u0131 olabilir?<\/strong><\/p>\n

\u00a0M\u00fcmk\u00fcn oldu\u011funca ara\u015ft\u0131rmaya kat\u0131l\u0131n. \u0130yi bilgilendirilmi\u015f bir hasta veya ara\u015ft\u0131rma \u00f6znesi olun. Bu alanda devam eden fonlar\u0131 destekleyin (NIH, MDA, hastal\u0131\u011fa \u00f6zg\u00fc vak\u0131flar, bireysel ara\u015ft\u0131rmac\u0131lar). Federal senat\u00f6rleriniz ve temsilcilerinizle genel olarak, n\u00f6rom\u00fcsk\u00fcler hastal\u0131k ve sizin hastal\u0131\u011f\u0131n\u0131zla ilgili ara\u015ft\u0131rmalar i\u00e7in NIH deste\u011finin devam etmesinin \u00f6nemi hakk\u0131nda konu\u015fun. Hikayenizi anlat\u0131n.\u00a0<\/p>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":4376,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[91,92],"tags":[],"class_list":["post-3227","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-researcher-interview","category-researcher"],"acf":[],"yoast_head":"\nLGMD RESEARCHER: Katherine Mathews - LGMD Awareness Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.lgmd-info.org\/tr\/researcher-interview\/2020\/04\/15\/lgmd-researcher-katherine-mathews\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" 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